Published | August 12, 2026 | Last Updated: August 12, 2026
Medical Reviewer | Dr. Yumin Lee at MeSOnBOM Clinic
Hello.
This is Dr. Yumin Lee from MeSOnBOM Clinic.
The skin around the eyes is particularly thin and delicate compared to other areas of the face.
Fine lines tend to develop more quickly in this area, and once they appear, there are limitations to managing them through home care alone.
Today, we will discuss a treatment that may help improve fine lines around the eyes.
It is Rejuran i. In this article, we will take a closer look at how Rejuran i can help improve fine lines around the eyes from a medical perspective.
Rejuran i is a treatment that involves injecting polynucleotide (PN), a regenerative substance derived from salmon, directly into the dermal layer of the skin to support the skin’s natural regenerative process.

Rejuran i contains the same active ingredient as the original Rejuran, but it has been specially formulated with a lower viscosity and a more fluid texture to make it easier to inject into the thin and sensitive skin around the eyes.
Unlike a sheet mask, which mainly provides moisture to the surface of the skin, Rejuran i may help support the regeneration of the epidermal and dermal layers of thin, lax skin. Rather than relying on artificial stimulation, it works by supporting the skin’s own regenerative capacity and its natural recovery process.
| Category | Rejuran Healer | Rejuran i |
|---|---|---|
| Primary treatment areas | Entire face, cheeks, and areas with reduced elasticity | Around the eyes, under-eye area, and other areas with thin skin |
| Formulation | Higher viscosity and elasticity | Lower viscosity, with a relatively fluid and soft texture |
| Injection layer | Mid-to-deep dermis | Superficial dermis |
| Duration of injection bumps | Approximately 24–48 hours | Approximately 12–24 hours |
Rejuran i directly improves inner elasticity, fine lines, skin dryness, and vascular dark circles by thickening the thin dermal layer around the eyes.

For 3–7 days after treatment, it is recommended to avoid environments and activities that may irritate the skin.
Moisturization and sun protection should also be maintained until temporary effects such as injection bumps or bruising have subsided.

Q1. Is Rejuran i painful?
Rejuran i uses a lower-viscosity formulation and a fine needle designed for the delicate eye area, so it tends to cause relatively less discomfort than standard Rejuran. A topical numbing cream is applied before the treatment to help reduce discomfort.
Q2. When do the effects begin to appear, and how many treatments are recommended?
Approximately 1–2 weeks after treatment, you may notice reduced dryness and smoother skin texture. To consistently support the skin’s natural regenerative capacity, it is recommended to receive the treatment at 3–4-week intervals for three or more sessions.
Q3. Can Rejuran i also help improve dark circles under the eyes?
In cases where dark circles are caused by the underlying blood vessels or structures showing through due to thin skin under the eyes, Rejuran i may help improve the appearance by making the dermal layer denser and increasing skin thickness, which may result in a brighter-looking appearance.
The eye area is an important part of the face that plays a significant role in determining overall facial impressions, which is why it requires delicate care.
Rejuran i takes a fundamental approach by activating the skin’s natural ability to regenerate itself, helping to improve fine lines around the eyes, elasticity, and dark circles at the same time.
Of course, since each person’s skin condition and desired results are different, it is most important to develop a treatment plan that is suitable for you through a thorough consultation with a medical professional.

Author | Dr. Yumin Lee
Medical Institution | MeSOnBOM Clinic